The role of IgG N-galactosylation in spondyloarthritis

Spondyloarthritis (SpA) is a group of chronic inflammatory arthritic diseases causing back pain and stiffness, leading to irreversible damage joint spine, seriously affecting the quality life. However, exact pathogenesis SpA still unknown, although blockers tumor necrosis factor (TNF) are major therapeutic advance. Of interest association between Immunoglobulin G (IgG) N-glycosylation. IgG N-glycosylation process post-translational modification (PTM) that takes part in regulating anti- pro-inflammatory effects. A relationship development exists, addition this often occurs before onset disease. There studies reporting SpA, significant amount data being generated. Analysis rigorous form greatly needed, hence review will focus on identifying relationships exist arthritis. More specifically, structure via TNF as treatment, link disease activity N-glycosylation, predictive capacity SpA. Investigation has demonstrated N-galactosylation plays an important role prognosis This provides novel pathway further research improve early diagnosis possible biomarkers for treatment patients with